Thiolase-like <p>This entry represents a structural domain with a thiolase-like 3-layer alpha/beta/alpha topology. This domain usually occurs in two similar copies that are related by a pseudo-dyad, and which arose through duplication. The proteins in this entry can be split into two groups: those related to thiolase, and those related to chalcone synthase. The thiolase-like enzymes include:</p><p> <ul><li>Thiolase, where the topology of each domain is similar to the first domain of phosphoglucomutase [<cite idref="PUB00020434"/>]</li><li>Beta-ketoacyl-ACP synthases types I (<db_xref db="EC" dbkey="2.3.1.41"/>) and II (<db_xref db="EC" dbkey="2.3.1.179"/>) [<cite idref="PUB00036842"/>, <cite idref="PUB00019762"/>]</li><li>Actinorhodin polyketide beta-ketoacyl synthases 1 and 2 [<cite idref="PUB00031547"/>]</li><li>Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase; <db_xref db="EC" dbkey="2.3.1.16"/>) [<cite idref="PUB00032244"/>]</li></ul> </p><p>The chalcone synthase-like enzymes include:</p><p> <ul><li>Chalcone synthase (<db_xref db="EC" dbkey="2.3.1.74"/>) [<cite idref="PUB00014381"/>]</li><li>Ketoacyl-ACP synthase III (FabH; <db_xref db="EC" dbkey="2.3.1.180"/>) [<cite idref="PUB00025721"/>]</li><li>Polyketide synthases [<cite idref="PUB00031426"/>]</li><li>3-hydroxy-3-methylglutaryl CoA synthase (<db_xref db="EC" dbkey="2.3.3.10"/>) [<cite idref="PUB00016103"/>]</li><li>Dihydropinosylvin synthase [<cite idref="PUB00031633"/>]</li></ul> </p>